Fast Phylogeny Reconstruction Through Learning of Ancestral Sequences
نویسندگان
چکیده
منابع مشابه
Reconstruction of ancestral nucleotide sequences and estimation of substitution frequencies in a star phylogeny.
Maximum likelihood phylogeny reconstruction methods are widely used in uncovering and assessing the evolutionary history and relationships of natural systems. However, several simplifying assumptions commonly made in this analysis limit the explanatory power of the results obtained. We present an algorithm that performs the phylogenetic analysis without making the common assumptions for sequenc...
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This chapter introduces the problem of ancestral sequence reconstruction: given a set of extant orthologous DNA genomic sequences (or even whole-genomes), together with a phylogenetic tree relating these sequences, predict the DNA sequence of all ancestral species in the tree. Blanchette et al. (1) have shown that for certain sets of species (in particular, for eutherian mammals), very accurate...
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The problem of ancestral sequence reconstruction is the statistical inference of sequences that correspond to internal nodes in a phylgenetic tree [1]. Joint reconstruction is the task of seeking the most likely set of ancestral states corresponding to all the ancestral taxa, while marginal reconstruction aims at inferring the sequence in a specific internal node. In simple probabilistic models...
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A challenging task in computational biology is the reconstruction of genomic sequences of extinct ancestors, given the phylogenetic tree and the sequences at the leafs. This task is best solved by calculating the most likely estimate of the ancestral sequences, along with the most likely edge lengths. We deal with this problem and also the variant in which the phylogenetic tree in addition to t...
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Whole genome doubling (WGD), a frequent occurrence during the evolution of the angiosperms, complicates ancestral gene order reconstruction due to the multiplicity of solutions to the genome halving process. Using the genome of a related species (the outgroup) to guide the halving of a WGD descendant attenuates this problem. We investigate a battery of techniques for further improvement, includ...
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ژورنال
عنوان ژورنال: Algorithmica
سال: 2012
ISSN: 0178-4617,1432-0541
DOI: 10.1007/s00453-012-9644-4